氧化亚氮对心理运动测试表现的影响。一项剂量反应研究。

The effect of nitrous oxide on the performance of psychomotor tests. A dose-response study.

作者信息

Cheam E W, Dob D P, Skelly A M, Lockwood G G

机构信息

Department of Anaesthesia, Royal Postgraduate Medical School, Hammersmith Hospital, London.

出版信息

Anaesthesia. 1995 Sep;50(9):764-8. doi: 10.1111/j.1365-2044.1995.tb06136.x.

DOI:10.1111/j.1365-2044.1995.tb06136.x

PMID:7573864

Abstract

The effect of different nitrous oxide concentrations on the performance of psychomotor tests (inspection time, tapping frequency, critical flicker fusion, picture memory and time sense) was investigated in seven healthy volunteers. The results show a dose-related impairment of memory, a reduction in tapping frequency and an increase in inspection time. A paradoxical increase in critical flicker-fusion threshold was observed. There was no effect on critical fusion-flicker threshold or time sense. Recovery was incomplete for memory tests performed 20 min after withdrawal of nitrous oxide. Subjective effects persisted for several hours.

摘要

研究了七种不同浓度一氧化二氮对七名健康志愿者心理运动测试（检查时间、敲击频率、临界闪烁融合、图像记忆和时间感知）表现的影响。结果显示，记忆存在剂量相关损伤，敲击频率降低，检查时间增加。观察到临界闪烁融合阈值出现反常增加。对临界融合闪烁阈值或时间感知没有影响。一氧化二氮停用20分钟后进行的记忆测试恢复不完全。主观影响持续数小时。