Charet J C, Leprêtre A, Watine J, Jounieaux V, Aron C, Charet P
Service de pneumologie et réanimation pneumologique, hôpital Sud, CHU Amiens, France.
Ann Biol Clin (Paris). 1995;53(3):131-4.
Lung cancer is a common pathology with high mortality due to late diagnosis. The 1987 TNM classification clearly defines the different steps and their prognosis. Although the prognostic value of some biological parameters (mainly serum LDH, sodium and/or albumin) has been established, these are not much used. We have prospectively studied the serum levels of seven proteins (RBP, prealbumin, albumin, transferrin, haptoglobin, orosomucoid, CRP) and we demonstrate the predominant value of prealbumin for the establishment of the prognosis of lung cancer; determination of orosomucoid increases the prognostic value of prealbumin. We confirm, for lung cancer, the prognostic value of the orosomucoid-prealbumin ratio, already known for other cancers.
肺癌是一种常见的病理类型,因其诊断较晚而死亡率很高。1987年的TNM分类明确界定了不同阶段及其预后情况。尽管一些生物学参数(主要是血清乳酸脱氢酶、钠和/或白蛋白)的预后价值已经得到确认,但这些参数并未得到广泛应用。我们前瞻性地研究了七种蛋白质(视黄醇结合蛋白、前白蛋白、白蛋白、转铁蛋白、触珠蛋白、类粘蛋白、C反应蛋白)的血清水平,并且证明了前白蛋白在肺癌预后评估中的主要价值;测定类粘蛋白可提高前白蛋白的预后评估价值。我们证实,对于肺癌而言,类粘蛋白与前白蛋白的比值具有预后评估价值,这在其他癌症中已为人所知。