Hashimoto N, Kohno H, Kubota H, Hayashi T, Uchida M, Yamanoi A, Ono T, Nagasue N
Second Dept. of Surgery, Shimane Medical University.
Gan To Kagaku Ryoho. 1995 Sep;22(11):1586-9.
In the present study, repeated hepatic dearterialization combined with intra-arterial infusion chemotherapy was performed in patients with unresectable tumors of the liver. Of 36 patients, 16 had primary liver tumors (13 hepatocellular carcinomas and 3 cholangiocellular carcinomas), while 20 had metastatic tumors (7 gastric carcinomas, 10 colon carcinomas, 2 pancreatic carcinomas, and 1 gastric carcinoid). A significantly better survival outcome was found in those with intra-arterial infusion chemotherapy and those without cirrhosis. In the HCC cases, those with the therapy tended to show a better survival as compared with the natural history. Remarkable tumor regression was found in four (67%) of six patients with metastases of gastric cancer.
在本研究中，对无法切除的肝脏肿瘤患者实施了重复肝动脉去血管化联合动脉内灌注化疗。36例患者中，16例为原发性肝肿瘤（13例肝细胞癌和3例胆管细胞癌），20例为转移性肿瘤（7例胃癌、10例结肠癌、2例胰腺癌和1例胃类癌）。动脉内灌注化疗患者和无肝硬化患者的生存结果明显更好。在肝细胞癌病例中，接受该治疗的患者与自然病程相比往往显示出更好的生存率。在6例胃癌转移患者中有4例（67%）出现了显著的肿瘤消退。
