Aractingi S, Mallet V, Pinquier L, Chosidow O, Vignon-Pennamen M D, Degos L, Dubertret L, Dombret H
Department of Dermatology, Hôpital Saint-Louis, Paris, France.
Arch Dermatol. 1995 Oct;131(10):1141-5.
Noninfectious cutaneous neutrophilic lesions can occur during granulocytopenia, but their mechanism remains unknown. We undertook a retrospective study of the neutrophilic dermatoses that developed during granulocytopenia induced by chemotherapy for acute myelogenous leukemia.
Seven men and one woman were included (2.6% of treated cases of acute myelogenous leukemia); half had acute myelogenous leukemia subtypes 4 and 5. The male-to-female ratio was 7:1. Neutrophilic eccrine hidradenitis was diagnosed in five cases, Sweet's syndrome in two cases, and difficult-to-classify neutrophilic dermatoses in one case. Cutaneous lesions appeared 12.5 days after the start of chemotherapy, and the mean leukocyte count was 0.426 x 10(9)/L. Three patients needed corticosteroids systemically.
Neutrophilic dermatoses during chemotherapy-induced granulocytopenia seem to occur more frequently in men with acute myelogenous leukemia subtypes 4 and 5.
非感染性皮肤中性粒细胞性病变可在粒细胞减少期间发生，但其机制仍不清楚。我们对急性髓性白血病化疗诱导粒细胞减少期间发生的中性粒细胞性皮肤病进行了一项回顾性研究。
纳入7名男性和1名女性（占急性髓性白血病治疗病例的2.6%）；半数患有急性髓性白血病4型和5型。男女比例为7:1。5例诊断为中性粒细胞性小汗腺汗管炎，2例为Sweet综合征，1例为难以分类的中性粒细胞性皮肤病。皮肤病变在化疗开始后12.5天出现，平均白细胞计数为0.426×10⁹/L。3例患者需要全身使用皮质类固醇。
化疗诱导粒细胞减少期间的中性粒细胞性皮肤病似乎在患有急性髓性白血病4型和5型的男性中更常见。
