Perrine K, Hermann B P, Meador K J, Vickrey B G, Cramer J A, Hays R D, Devinsky O
Department of Neurology, New York (NY) University School of Medicine, USA.
Arch Neurol. 1995 Oct;52(10):997-1003. doi: 10.1001/archneur.1995.00540340089017.
To examine the relationship of objectively assessed cognitive functioning to self-reported quality of life.
Correlational, multiple regression, and factor analytic comparisons of a new self-report quality of life inventory with neuropsychological tests of cognition and mood.
Two hundred fifty-seven patients with epilepsy.
Twenty-five epilepsy centers and neurology clinics across the United States.
A recently developed self-report (ie, Quality of Life in Epilepsy-89 inventory) and objective tests of memory, verbal abilities, spatial functions, psychomotor and cognitive processing speed, cognitive flexibility, and mood.
Factors that assessed mood, psychomotor speed, verbal memory, and language correlated significantly with selected scales of the Quality of Life in Epilepsy-89 inventory (P < .0001) and were predictive of overall quality of life (P < .002 to P < .0001). The mood factor showed the highest correlations (r = -.20 to r = -.73) and was the strongest predictor of quality of life in regression analyses (46.7% explained variance, P < .0001).
Mood may be adversely affected by diminished quality of life, or perceived quality of life may be affected by mood disturbance. Quantitative quality of life assessments can be used in conjunction with formal neuropsychological testing of mood and cognition when evaluating patients with epilepsy.
探讨客观评估的认知功能与自我报告的生活质量之间的关系。
将一种新的自我报告生活质量量表与认知和情绪的神经心理学测试进行相关性、多元回归和因子分析比较。
257例癫痫患者。
美国25个癫痫中心和神经内科诊所。
一种最近开发的自我报告量表（即癫痫生活质量-89量表）以及记忆、语言能力、空间功能、心理运动和认知处理速度、认知灵活性和情绪的客观测试。
评估情绪、心理运动速度、言语记忆和语言的因素与癫痫生活质量-89量表的选定量表显著相关（P <.0001），并可预测总体生活质量（P <.002至P <.0001）。情绪因子显示出最高的相关性（r = -.20至r = -.73），并且在回归分析中是生活质量的最强预测因子（解释方差46.7%，P <.0001）。
生活质量下降可能对情绪产生不利影响，或者情绪障碍可能影响感知到的生活质量。在评估癫痫患者时，生活质量的定量评估可与情绪和认知的正式神经心理学测试结合使用。
