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Selective inhibition of steroid 5 alpha-reductase isozymes by tea epicatechin-3-gallate and epigallocatechin-3-gallate.

作者信息

Liao S, Hiipakka R A

机构信息

Ben May Institute, University of Chicago, IL 60637, USA.

出版信息

Biochem Biophys Res Commun. 1995 Sep 25;214(3):833-8. doi: 10.1006/bbrc.1995.2362.

DOI:10.1006/bbrc.1995.2362
PMID:7575552
Abstract

Inhibitors of 5 alpha-reductase may be effective in the treatment of 5 alpha-dihydrotestosterone-dependent abnormalities, such as benign prostate hyperplasia, prostate cancer and certain skin diseases. The green tea catechins, (-)epigallocatechin-3-gallate and (-)epicatechin-3-gallate, but not (-)epicatechin and (-)epigallocatechin, are potent inhibitors of type 1 but not type 2 5 alpha-reductase. (-)Epigallocatechin-3-gallate also inhibits accessory sex gland growth in the rat. These results suggest that certain tea gallates can regulate androgen action in target organs.

摘要

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