Shindo K, Hirai Y, Koide K, Sumitomo M, Fukumura M
First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
Biochem Biophys Res Commun. 1995 Sep 25;214(3):869-74. doi: 10.1006/bbrc.1995.2367.
We investigated the release of leukotriene C4 from eosinophils of asthmatic patients who were treated with or without intravenous prednisolone. The mean level of LTC4 in the supernatant of A23187-stimulated eosinophils obtained from asthmatic patients during an attack was significantly lower with intravenous prednisolone than without prednisolone treatment. Findings suggest that intravenous prednisolone inhibits the release of LTC4 from the eosinophils of asthmatic patients by acting on these cells in vivo.
我们研究了接受或未接受静脉注射泼尼松龙治疗的哮喘患者嗜酸性粒细胞中白三烯C4的释放情况。在哮喘发作期间，接受静脉注射泼尼松龙治疗的哮喘患者经A23187刺激的嗜酸性粒细胞上清液中LTC4的平均水平显著低于未接受泼尼松龙治疗的患者。研究结果表明，静脉注射泼尼松龙通过在体内作用于这些细胞来抑制哮喘患者嗜酸性粒细胞中LTC4的释放。
