Thalmann I, Shibasaki O, Comegys T H, Henzl M T, Senarita M, Thalmann R
Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Biochem Biophys Res Commun. 1995 Oct 4;215(1):142-7. doi: 10.1006/bbrc.1995.2444.
A small, acidic calcium-binding protein (CBP-15) has been detected in the guinea pig organ of Corti, the auditory receptor organ. The apparent molecular weight (15,000) and very low isoelectric point (pI approximately 3.1) suggest that CBP-15 is a beta-parvalbumin isoform. Consistent with this hypothesis, CBP-15 exhibits extreme homology to the mammalian oncofetal parvalbumin called oncomodulin. Sequence data have now been obtained for 30 residues in the N-terminal third of CBP-15. Identity with oncomodulin is observed at all 30 positions. This finding could necessitate revision of the assumption that postnatal mammals utilize a single alpha-parvalbumin isoform in muscle and nonmuscle settings alike.
