Cunningham E B
Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry, New Jersey Medical School, Newark 07103-2714, USA.
Biochem Biophys Res Commun. 1995 Oct 4;215(1):212-8. doi: 10.1006/bbrc.1995.2455.
A 12-kDa inositolphosphate-binding protein has been identified as a component of the human erythrocyte membrane. Its robust peptidylprolyl cis-trans isomerase activity that is strongly inhibited by the immunosuppressant drugs FK506 and rapamycin indicates that it is an immunophilin belonging to the FKBP class. The finding that its peptidylprolyl cis-trans isomerase activity is also strongly inhibited by nanomolar concentrations of the second messengers inositol 1,4,5-trisphosphate (IP3) and inositol 1,3,4,5-tetrakisphosphate (IP4) suggests that IP3 and IP4 could be physiological ligands for this membrane-associated immunophilin.
一种12千道尔顿的肌醇磷酸结合蛋白已被鉴定为人红细胞膜的一个组成部分。其强大的肽基脯氨酰顺反异构酶活性受到免疫抑制剂FK506和雷帕霉素的强烈抑制，这表明它是一种属于FKBP类的亲免素。其肽基脯氨酰顺反异构酶活性也受到纳摩尔浓度的第二信使肌醇1,4,5-三磷酸（IP3）和肌醇1,3,4,5-四磷酸（IP4）的强烈抑制，这一发现表明IP3和IP4可能是这种膜相关亲免素的生理配体。
