van Berg A A, Mooyer P A, van Lenthe H, Stet E H, De Abreu R A, van Kuilenburg A B, van Gennip A H
Academic Medical Center, University of Amsterdam, Department of Pediatrics, The Netherlands.
Biochem Pharmacol. 1995 Sep 28;50(7):1095-8. doi: 10.1016/0006-2952(95)00228-r.
Mycophenolic acid, an inhibitor of the enzyme IMP dehydrogenase, antagonizes the CTP synthetase inhibitor 3-deazauridine in its anti-proliferative effects on MOLT-3 human T leukemia cells. No depletion of CTP occurred, and decreased amounts of 3-deazuridine-triphosphate were measured in cells incubated with mycophenolic acid and 3-deazuridine. Most probably, these phenomena are related to the increased amounts of PRPP observed, which can result in an increased pyrimidine biosynthesis de novo and, as a consequence, a decreased metabolism of 3-deazauridine via the salvage pathway.
