Lusk R H, Wienke E C, Milligan T W, Albus T E
St. Louis University School of Medicine, Missouri.
Arthritis Rheum. 1995 Sep;38(9):1325-7. doi: 10.1002/art.1780380921.
This case report describes loosening of a right knee prosthesis and represents the first report of the simultaneous occurrence of 2 granulomatous processes involving a prosthetic joint. Microscopic examination of the tissue revealed areas of foreign-body granulomas and areas of necrotizing granulomas and caseation. Acid-fast bacilli cultures were positive for Mycobacterium tuberculosis. The pathophysiology of implant loosening following an inflammatory reaction to components of prosthetic materials is discussed. Also discussed is the occurrence of infectious complications and rarity of tuberculous infections associated with prosthetic implants.
本病例报告描述了一例右膝假体松动的情况，这是首例关于涉及人工关节的两种肉芽肿性病变同时发生的报告。对组织进行显微镜检查发现了异物肉芽肿区域、坏死性肉芽肿区域和干酪样坏死区域。抗酸杆菌培养结果显示结核分枝杆菌呈阳性。文中讨论了对假体材料成分发生炎症反应后植入物松动的病理生理学。还讨论了感染并发症的发生情况以及与假体植入相关的结核感染的罕见性。
