Fuchigami T, Okubo O, Ejiri K, Fujita Y, Kohira R, Noguchi Y, Fuchigami S, Hiyoshi K, Nishimura A, Harada K
Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan.
Pediatr Neurol. 1995 Jul;13(1):25-8. doi: 10.1016/0887-8994(95)00086-u.
Age-related correlations on auditory event-related potentials were studied using a task-relevant oddball paradigm in 175 normal subjects aged 4-21 years and age-related correlations in the "ignore" condition were studied in 108 normal subjects aged 1-21 years. In the ignore condition, subjects more than 4 years of age were instructed to read a book to divert attention from the auditory stimulus. From 4 to about 17 years of age, the latencies of task-relevant P300 in event-related potentials (ERPs) gradually shortened. In the ignore condition experiment, the P300 latency shortened progressively, but stabilized at about 12 years of age. Whereas P300 in the ignore condition likely corresponds to P3a described previously (passive attention), the conventional P300 wave corresponds to P3b (active attention). The findings indicate a developmental difference between the P3a and P3b potential.
在175名4至21岁的正常受试者中，使用与任务相关的oddball范式研究了听觉事件相关电位与年龄的相关性；在108名1至21岁的正常受试者中，研究了“忽略”条件下与年龄的相关性。在忽略条件下，4岁以上的受试者被要求阅读一本书，以转移对听觉刺激的注意力。从4岁到大约17岁，事件相关电位（ERP）中与任务相关的P300潜伏期逐渐缩短。在忽略条件实验中，P300潜伏期逐渐缩短，但在大约12岁时稳定下来。忽略条件下的P300可能对应于先前描述的P3a（被动注意力），而传统的P300波对应于P3b（主动注意力）。研究结果表明P3a和P3b电位之间存在发育差异。
