Raheja R K, Bharwani I, Penetrante A E
Department of Psychiatry, Broughton Hospital, Morganton, North California, USA.
J Geriatr Psychiatry Neurol. 1995 Jul;8(3):159-61. doi: 10.1177/089198879500800303.
Standard antipsychotics are ineffective in some geriatric patients. In addition, they are not helpful for apathy and withdrawal. Studies have demonstrated that 5HT2 antagonists improve affective symptoms and anxiety; therefore, the efficacy of risperidone on agitation and withdrawal was considered. The literature on risperidone was reviewed, and the efficacy and limitations of risperidone observed in two geriatric patients, one with agitation and another with apathy and withdrawal. Risperidone proved to be effective in controlling disruptive behavior in geriatric patients. Combined antagonism of D2 and 5HT2 receptors might be effective in improving agitation and withdrawal. Risperidone, with both D2 and 5HT2 antagonistic properties, seems to have potential as an alternative agent in controlling agitation and withdrawal in geriatric patients. Caution and need for further observation is recommended.
