Bergelson L D
School of Pharmacy, Hebrew University of Jerusalem, Ein Kerem, Israel.
Immunol Today. 1995 Oct;16(10):483-6. doi: 10.1016/0167-5699(95)80032-8.
Gangliosides suppress various immune activities in vitro and in vivo. Their level is significantly elevated in tumors and atherosclerotic aorta tissue, as well as in the sera of patients with tumors or atherosclerosis. Here, Lev Bergelson suggests that ganglioside-induced immunomodulation might be involved in atherogenesis and carcinogenesis, and describes a hypothesis that cites gangliosides as a factor interfering with the clearance of low-density lipoproteins (LDLs) and promoting the formation of atherosclerotic plaques.
神经节苷脂在体外和体内均可抑制多种免疫活动。在肿瘤、动脉粥样硬化主动脉组织以及肿瘤或动脉粥样硬化患者的血清中，其水平显著升高。在此，列夫·伯格elson指出，神经节苷脂诱导的免疫调节可能参与动脉粥样硬化和癌症的发生，并描述了一种假说，该假说认为神经节苷脂是干扰低密度脂蛋白（LDL）清除并促进动脉粥样硬化斑块形成的一个因素。
