Ville Y, Vincent Y, Tordjman N, Hue M V, Fernandez H, Frydman R
Département de Gynécologie-Obstétrique, Hôpital A. Béclère, Clamart, France.
Fetal Diagn Ther. 1995 Sep-Oct;10(5):301-6. doi: 10.1159/000264248.
The effects of corticosteroids, given for enhancement of fetal lung maturation, on fetal heart rate (FHR) are controversial and may decrease its variability. FHR patterns were analyzed by computerized cardiotocography in 46 fetuses from 23 normal dichorionic twin pregnancies on days 0, 1 and 4-7 while the mothers received four intramuscular injections of 3 mg betamethasone sodium and 3 mg betamethasone acetate within 48 h to enhance fetal lung maturation. Compared with pretreatment values, FHR showed a decrease in long- and short-term variations; other parameters, e.g. the number of fetal movements, remained unchanged. However, decreased FHR variation was followed by an increase in the acceleration rate after maternal administration of betamethasone. These modifications were transient and should not lead to unnecessary anxiety or intervention in otherwise normal fetuses.
为促进胎儿肺成熟而给予的皮质类固醇对胎儿心率（FHR）的影响存在争议，且可能降低其变异性。在23例正常双绒毛膜双胎妊娠的46例胎儿中，于第0天、第1天以及第4 - 7天通过计算机化胎心监护分析FHR模式，在此期间母亲在48小时内接受了4次肌肉注射，每次注射3毫克倍他米松钠和3毫克倍他米松醋酸酯以促进胎儿肺成熟。与治疗前的值相比，FHR的长期和短期变异性均降低；其他参数，如胎动次数，保持不变。然而，母亲给予倍他米松后，FHR变异性降低后加速率增加。这些变化是短暂的，不应导致对其他方面正常的胎儿产生不必要的焦虑或干预。
