Hayes R, Mosha F, Nicoll A, Grosskurth H, Newell J, Todd J, Killewo J, Rugemalila J, Mabey D
London School of Hygiene and Tropical Medicine, UK.
AIDS. 1995 Aug;9(8):919-26. doi: 10.1097/00002030-199508000-00014.
To describe the rationale and design of a randomized trial of the impact of improved services for the treatment of sexually transmitted diseases (STD) on the incidence of HIV infection in Mwanza Region, Tanzania.
The likely impact of improved STD treatment services on HIV incidence, and the need for empirical information on the effectiveness of this intervention strategy, are discussed. The rationale and design of such an intervention programme in Mwanza Region, and of a community-randomized trial to measure the impact of the programme on HIV and other STD, are presented. Problems in the design and interpretation of the trial are reviewed.
Results of the baseline survey of the cohort of over 12,000 adults in 12 communities are presented in a companion paper.
There is an urgent need for effective preventive measures against the HIV epidemic in sub-Saharan Africa and other developing regions. Improved STD treatment has been promoted as a potentially effective strategy, but there is little empirical information on its impact. The trial in Mwanza Region is the first randomized study of this intervention and should provide valuable data for health policy makers.
描述一项关于改善性传播疾病（STD）治疗服务对坦桑尼亚姆万扎地区艾滋病毒感染率影响的随机试验的基本原理和设计。
讨论了改善性传播疾病治疗服务对艾滋病毒感染率可能产生的影响，以及获取有关该干预策略有效性实证信息的必要性。介绍了姆万扎地区此类干预项目的基本原理和设计，以及一项用于衡量该项目对艾滋病毒和其他性传播疾病影响的社区随机试验。回顾了该试验在设计和解读方面存在的问题。
一篇配套论文展示了对12个社区中12000多名成年人队列进行基线调查的结果。
撒哈拉以南非洲和其他发展中地区迫切需要有效的艾滋病毒流行预防措施。改善性传播疾病治疗已被推崇为一种潜在有效的策略，但关于其影响的实证信息很少。姆万扎地区的试验是对该干预措施的首次随机研究，应为卫生政策制定者提供有价值的数据。
