布舍瑞林和戈那瑞林在混悬液中的生物利用度。
Bioavailability of buserelin and gonadorelin in suspensions.
作者信息
Dolińska B, Ryszka F, Szulc B
机构信息
Department of Applied Pharmacy and Drug Technology, Silesian Medical Academy, Sosnowiec, Poland.
出版信息
Boll Chim Farm. 1995 Sep;134(8):459-60.
PMID:7576445
Abstract
There have been determined parameters defining biological availability of gonadorelin and buserelin marked 125 J. Hormonal preparations were hypodermically administered to the rats in suspensions containing zinc ions of the molar ratio of the hormone: zinc 1:5. It has been stated that buserelin in suspension is better available to an organism than gonadorelin .
摘要
已经确定了定义标记为125 J的促性腺激素释放激素和布舍瑞林生物利用度的参数。将激素制剂皮下注射到含有锌离子的悬浮液中的大鼠体内，激素与锌的摩尔比为1:5。结果表明，悬浮液中的布舍瑞林比促性腺激素释放激素对机体的可用性更好。
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