Puiggròs Boldú S, Pujol Cubells M, Girona Brumós V, Prat Aixelà J, Muñoz Juncosa M
Unitat de Físico-Química, Facultat de Farmàcia, Universitat de Barcelona.
Boll Chim Farm. 1995 Sep;134(8):467-71.
The kinetics of degradation of azlocillin sodium in four intravenous admixtures was investigated at different temperatures. The effect of temperature has been determined and from this data, by applying of Arrhenius-law, the stability of azlocillin sodium at 25 degrees C has been predicted and the t90 was determined. Admixtures containing azlocillin sodium (0.01 g ml-1) were prepared in 0.9% sodium chloride injection, in 5% dextrose solution, in 5% levulose solution and in Ringer's lactate solution. The admixtures were stored at 30 degrees, 40 degrees and 50 degrees C in either polyvinyl chloride bags and glass bottles. The change in the initial azlocillin sodium concentration was related to the type of intravenous solution. No dependence with material of container was found. After 24 hours, the change in the initial concentration of penicillin was less than 10% of the initial concentration in 0.9% sodium chloride and 5% levulose solution. However in Ringer's lactate and 5% glucose solution the t90 was lower. These results were found in agreement with experimental ones obtained at room temperature.
在不同温度下研究了阿洛西林钠在四种静脉输液中的降解动力学。确定了温度的影响，并根据这些数据，应用阿仑尼乌斯定律预测了阿洛西林钠在25℃时的稳定性并确定了t90。含有阿洛西林钠（0.01 g/ml）的混合液分别在0.9%氯化钠注射液、5%葡萄糖溶液、5%果糖溶液和乳酸林格氏液中配制。混合液分别储存在30℃、40℃和50℃的聚氯乙烯袋和玻璃瓶中。阿洛西林钠初始浓度的变化与静脉输液的类型有关。未发现与容器材料有关。24小时后，0.9%氯化钠和5%果糖溶液中青霉素初始浓度的变化小于初始浓度的10%。然而，在乳酸林格氏液和5%葡萄糖溶液中t90较低。这些结果与在室温下获得的实验结果一致。
