溃疡性结肠炎和原发性硬化性胆管炎中的人类白细胞抗原

HLA antigens in ulcerative colitis and primary sclerosing cholangitis.

作者信息

Leidenius M H, Koskimies S A, Kellokumpu I H, Höckerstedt K A

机构信息

Fourth Department of Surgery, Helsinki University Central Hospital, Finland.

出版信息

APMIS. 1995 Jul-Aug;103(7-8):519-24. doi: 10.1111/j.1699-0463.1995.tb01400.x.

DOI:10.1111/j.1699-0463.1995.tb01400.x

PMID:7576567

Abstract

The aims of this study were to find out whether the alleles of the HLA class I or II region are associated with susceptibility to ulcerative colitis, and to show whether there is a difference or similarity in HLA associations between primary sclerosing cholangitis and ulcerative colitis. HLA-A, B, C and DR antigens were studied using the standard lymphocyte microcytotoxicity test in 24 Finnish patients with primary sclerosing cholangitis, 77 patients with ulcerative colitis, and 106 controls. HLA-B8 (54%) and DR3 (60%) were associated with primary sclerosing cholangitis. HLA-DR1 (46%) and DR6 (20%) seemed more common in ulcerative colitis than in controls. A positive association with Cw7 was common to both ulcerative colitis (25%) and primary sclerosing cholangitis (33%). Our results indicate that ulcerative colitis is more heterogeneous than primary sclerosing cholangitis in its HLA-DR associations.

摘要

本研究的目的是查明HLA I类或II类区域的等位基因是否与溃疡性结肠炎易感性相关，并表明原发性硬化性胆管炎与溃疡性结肠炎在HLA相关性方面是否存在差异或相似性。采用标准淋巴细胞微量细胞毒性试验，对24例芬兰原发性硬化性胆管炎患者、77例溃疡性结肠炎患者和106例对照者进行了HLA - A、B、C和DR抗原研究。HLA - B8（54%）和DR3（60%）与原发性硬化性胆管炎相关。HLA - DR1（46%）和DR6（20%）在溃疡性结肠炎患者中似乎比对照组更为常见。溃疡性结肠炎（25%）和原发性硬化性胆管炎（33%）均与Cw7呈正相关。我们的结果表明，溃疡性结肠炎在HLA - DR相关性方面比原发性硬化性胆管炎更为异质性。