Grgicević D, Bozović I, Pende B
Bilt Hematol Transfuz. 1978;6(3):13-29.
Blood component therapy has been wildly accepted all over the world due to the better effects achieved in treating the patients, its safety and economy. In SRH it is replacing whole blood transfusions rather slowly as can be seen through five years of production and utilisation of blood derivatives. In 1974-1978 period a number of donations in Croatia increased to 27 per 1.000 inhabitants, but it is still very far from optimal 40-60 donations per 1.000 inhabitants. In that period the production of albumin increased 5 times, of immunoglobulins 10 times and factor VIII 10 times. In 1978 per 1.000 inhabitants, 2,1 1 of plasma were fractionated, 53 gr of albumin and 23 ml of imunoglobulins were used plus additional 6.200 units per one haemophiliac. These quantities are not sufficient to cover the needs of the health service in SRH. To overcome the shortage it is necessary to increase the number of donations, to augmant the average amount of donation to 450 ml., to increase the number of plasmapheresis and to use blood component therapy on a larger scale. Only after obtaining 10-12 1 of plasma for fractionation per 1.000 inhabitants optimal quantities of derivatives can be secured.
由于在治疗患者方面取得了更好的效果,且具有安全性和经济性,血液成分疗法在全世界已被广泛接受。在南斯拉夫社会主义联邦共和国(SRH),正如通过五年血液衍生物的生产和使用所看到的那样,它正在缓慢地取代全血输血。在1974 - 1978年期间,克罗地亚的献血量增加到每1000名居民27次,但仍远低于每1000名居民40 - 60次的最佳献血量。在那个时期,白蛋白的产量增加了5倍,免疫球蛋白增加了10倍,凝血因子VIII增加了10倍。1978年,每1000名居民中,有2.11升血浆被分离,使用了53克白蛋白和23毫升免疫球蛋白,另外每位血友病患者使用6200单位。这些数量不足以满足南斯拉夫社会主义联邦共和国卫生服务的需求。为了克服短缺,有必要增加献血次数,将平均献血量提高到450毫升,增加血浆置换次数,并更广泛地使用血液成分疗法。只有在每1000名居民获得10 - 12升用于分离的血浆后,才能确保获得最佳数量的衍生物。