Svane G, Rotstein S, Lax I
Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden.
Acta Oncol. 1995;34(6):845-9. doi: 10.3109/02841869509127195.
CT-assessed density changes in lung tissues were measured in 22 disease-free breast cancer patients 4 years after completion of radiation therapy. All patients had previously undergone similar CT-examinations before treatment, 3 months, and 9 months after radiotherapy. In patients with visible areas of increased lung density at earlier CT-examinations a decrease of focal findings was observed at 4 years. In patients without focal findings, an increase in density relative to that before therapy was observed. The difference between the mean lung density values among those with visible radiological findings and those without was statistically significant both at 3 and 9 months after therapy. However, this difference did not persist at 4 years. These results may indicate a 2-phase development of radiation-induced lung damages--an acute phase and a late phase; the late phase emerging slowly, and in this study detectable 4 years after completion of radiation therapy.
在22名无疾病的乳腺癌患者完成放射治疗4年后，测量了CT评估的肺组织密度变化。所有患者此前在治疗前、放疗后3个月和9个月均接受过类似的CT检查。在早期CT检查中肺部密度可见增加区域的患者中，4年时观察到局灶性病变减少。在无局灶性病变的患者中，观察到相对于治疗前密度增加。有可见放射学表现的患者与无可见放射学表现的患者之间的平均肺密度值差异在治疗后3个月和9个月均具有统计学意义。然而，这种差异在4年时并未持续存在。这些结果可能表明放射性肺损伤呈两阶段发展——急性期和晚期；晚期发展缓慢，在本研究中放射治疗完成4年后可检测到。
