神经母细胞瘤的分化与预后与CD44s表达的相关性

Differentiation and prognosis of neuroblastoma in correlation to the expression of CD44s.

作者信息

Terpe H J, Christiansen H, Gonzalez M, Berthold F, Lampert F

机构信息

Department of Pathology, Justus-Liebig University, Giessen, Germany.

出版信息

Eur J Cancer. 1995;31A(4):549-52. doi: 10.1016/0959-8049(95)00061-m.

DOI:10.1016/0959-8049(95)00061-m

PMID:7576965

Abstract

Cell-cell and cell-extracellular matrix interactions mediated by cell adhesion molecules (for example CD44) play an important role in the cascade of metastasis and the progression of human malignant tumours. The most important aim of this review was, on the basis of our results and the literature, to show the correlation between the expression of CD44s and differentiation and prognosis of neuroblastoma. Surprisingly and in contrast to most other malignant tumours, neuroblastomas exhibited an inverse correlation between CD44s expression and tumour progression. It can be stated that CD44s is a prognostic marker in neuroblastoma which correlates significantly with the grade of tumour cell differentiation, but not with clinical stage. Moreover, there exists a statistically significant correlation between MYCN oncogene amplification and the lack of CD44s expression.

摘要

由细胞黏附分子（如CD44）介导的细胞间以及细胞与细胞外基质的相互作用在人类恶性肿瘤转移级联反应和进展过程中发挥重要作用。本综述的最重要目的是，基于我们的研究结果及文献，揭示CD44s表达与神经母细胞瘤分化及预后之间的相关性。令人惊讶的是，与大多数其他恶性肿瘤相反，神经母细胞瘤中CD44s表达与肿瘤进展呈负相关。可以说，CD44s是神经母细胞瘤的一个预后标志物，它与肿瘤细胞分化程度显著相关，但与临床分期无关。此外，MYCN癌基因扩增与CD44s表达缺失之间存在统计学上的显著相关性。