Niethammer D, Handgretinger R
Children's University Hospital, Department of Pediatric Hematology/Oncology, Tübingen, Germany.
Eur J Cancer. 1995;31A(4):568-71. doi: 10.1016/0959-8049(95)00032-e.
Neuroblastoma is the most common solid extracranial tumour in childhood. In spite of intensive efforts of clinicians and scientists the prognosis for advanced disease is still poor. This paper presents a short review of the state-of-the-art in conventional treatment including surgery, chemotherapy, and radiation. This is followed by a review of the treatment attempts with high dose chemotherapy followed by autologous bone marrow or stem cell transplantation. One of the main problems with this approach is the contaminating tumour cells. Finally the various immunotherapeutic strategies are summarised which are used to remove minimal residual disease. Later, our new approach, combining various treatment modalities, is described.
神经母细胞瘤是儿童期最常见的实体颅外肿瘤。尽管临床医生和科学家付出了巨大努力，但晚期疾病的预后仍然很差。本文简要回顾了包括手术、化疗和放疗在内的传统治疗的现状。接下来回顾了高剂量化疗后进行自体骨髓或干细胞移植的治疗尝试。这种方法的主要问题之一是肿瘤细胞污染。最后总结了用于清除微小残留病灶的各种免疫治疗策略。随后，描述了我们结合多种治疗方式的新方法。
