[阿莫西林-克拉维酸诱导的肝毒性相关急性胰腺炎]
[Acute pancreatitis associated with hepatotoxicity induced by amoxicillin-clavulanic acid].
作者信息
Galindo C, Buenestado J, Reñé J M, Piñol M C
机构信息
Sección Digestivo, Hospital Arnau de Vilanova, Facultad de Medicina, Lleida.
出版信息
Rev Esp Enferm Dig. 1995 Aug;87(8):597-600.
A 25-year old man suffered from acute pancreatitis and cholestatic acute hepatitis simultaneously after 4 weeks of an antibiotic treatment withdrawal (amoxicillin plus clavulanic acid) which was given for pharyngitis. Other potential etiological causes of both acute pancreatitis and liver disease, were excluded. The causal relationship between amoxicillin plus clavulanic acid and cholestatic hepatitis is well know, but no data has been reported regarding acute pancreatitis. The medical literature is reviewed and the mechanisms of toxicity are discussed.
一名25岁男性在因咽炎接受抗生素治疗（阿莫西林加克拉维酸）停药4周后，同时患上了急性胰腺炎和胆汁淤积性急性肝炎。急性胰腺炎和肝病的其他潜在病因均被排除。阿莫西林加克拉维酸与胆汁淤积性肝炎之间的因果关系已为人熟知，但尚无关于急性胰腺炎的相关数据报道。本文对医学文献进行了综述，并讨论了毒性机制。
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