Del Puente A, Pappone N, Mandes M G, Mantova D, Nutile G, Maurelli L, Oriente P
Cattedra di Reumatologia, Università degli Studi Federico II di Napoli.
Ann Ital Med Int. 1995 Jul-Sep;10(3):163-6.
We studied a group of hemiplegic patients to determine the amount of bone loss of the paretic versus the normal limb and to evaluate the importance of several variables in determining this difference. Thirty consecutive subjects with hemiplegia caused by a cerebral vascular accident were studied: 15 postmenopausal women (average age 65.1 years) and 15 men (average age 58.3 years) (average age of entire group, 63.2 years; age range of entire group, 27-84 years). The mean duration of immobilization was 7.7 months for women (range 1-40 months) and 10.5 months for men (range 1-48 months). All subjects had a complete physical examination, underwent bilateral femoral neck DEXA, and filled out a questionnaire. The percent difference (delta) between the paretic and normal limb was 6.1% in the women and 3.8% in the men. Logistic regression analysis, after control for age and sex, indicated that the degree of demineralization depended significantly and directly on the duration of immobilization and depended inversely on the time elapsed since menopause. Our data evidence the importance of immobilization osteoporosis and point to the role of hormonal factors in its pathogenesis.
我们研究了一组偏瘫患者，以确定瘫痪肢体与正常肢体的骨质流失量，并评估几个变量在确定这种差异中的重要性。对30例连续的因脑血管意外导致偏瘫的受试者进行了研究：15名绝经后女性（平均年龄65.1岁）和15名男性（平均年龄58.3岁）（整个组的平均年龄为63.2岁；整个组的年龄范围为27 - 84岁）。女性的平均固定时间为7.7个月（范围1 - 40个月），男性为10.5个月（范围1 - 48个月）。所有受试者均进行了全面的体格检查，接受了双侧股骨颈双能X线吸收测定法（DEXA）检查，并填写了一份问卷。女性瘫痪肢体与正常肢体之间的百分比差异（δ）为6.1%，男性为3.8%。在控制年龄和性别后进行的逻辑回归分析表明，脱矿程度显著且直接取决于固定时间，并与绝经后经过的时间呈反比。我们的数据证明了固定性骨质疏松症的重要性，并指出了激素因素在其发病机制中的作用。
