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携带阿霉素的脂质体对小鼠乳腺癌转移的预防作用

Prevention of metastasis from mouse mammary carcinomas with liposomes carrying doxorubicin.

作者信息

Vaage J, Donovan D, Loftus T, Working P

机构信息

Department of Molecular Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

出版信息

Br J Cancer. 1995 Nov;72(5):1074-5. doi: 10.1038/bjc.1995.467.

DOI:10.1038/bjc.1995.467
PMID:7577449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2033931/
Abstract

Weekly treatments with doxorubicin encapsulated in long circulating, sterically stabilised liposomes (DOX-SL) reduced the incidence of metastases from primary mammary carcinoma from 24 of 47 untreated mice to 3 of 23 treated mice. Toxic side-effects were limited to minor, transient weight losses.

摘要

每周使用包裹在长循环、空间稳定脂质体中的阿霉素（DOX-SL）进行治疗，可使原发性乳腺癌转移的发生率从47只未治疗小鼠中的24只降低至23只治疗小鼠中的3只。毒性副作用仅限于轻微的、短暂的体重减轻。

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本文引用的文献

1
Therapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes.用包裹在空间稳定脂质体中的长春新碱和阿霉素治疗小鼠乳腺癌
Int J Cancer. 1993 Jul 30;54(6):959-64. doi: 10.1002/ijc.2910540616.
2
Tissue distribution and therapeutic effect of intravenous free or encapsulated liposomal doxorubicin on human prostate carcinoma xenografts.静脉注射游离或包裹脂质体阿霉素对人前列腺癌异种移植瘤的组织分布及治疗效果
Cancer. 1994 Mar 1;73(5):1478-84. doi: 10.1002/1097-0142(19940301)73:5<1478::aid-cncr2820730526>3.0.co;2-1.
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Spontaneous metastasis from primary C3H mouse mammary tumors.原发性C3H小鼠乳腺肿瘤的自发转移。
Cancer Res. 1987 Jan 15;47(2):547-50.
4
Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.具有延长的血液中循环时间和增强的肿瘤摄取能力的脂质体制剂。
Proc Natl Acad Sci U S A. 1988 Sep;85(18):6949-53. doi: 10.1073/pnas.85.18.6949.
5
Mammary tumorigenesis and tumor morphology in four C3H sublines with or without exogenous mammary tumor virus.四个有或没有外源性乳腺肿瘤病毒的C3H亚系中的乳腺肿瘤发生及肿瘤形态
Cancer Res. 1986 Apr;46(4 Pt 2):2096-100.
6
Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo.含有聚乙二醇合成脂质衍生物的脂质体在体内显示出延长的循环半衰期。
Biochim Biophys Acta. 1991 Jul 1;1066(1):29-36. doi: 10.1016/0005-2736(91)90246-5.
7
Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times.空间稳定脂质体：关于延长循环时间分子起源的一种假说。
Biochim Biophys Acta. 1991 Nov 18;1070(1):187-92. doi: 10.1016/0005-2736(91)90162-2.
8
Therapy of primary and metastatic mouse mammary carcinomas with doxorubicin encapsulated in long circulating liposomes.
Int J Cancer. 1992 Jul 30;51(6):942-8. doi: 10.1002/ijc.2910510618.