携带阿霉素的脂质体对小鼠乳腺癌转移的预防作用
Prevention of metastasis from mouse mammary carcinomas with liposomes carrying doxorubicin.
作者信息
Vaage J, Donovan D, Loftus T, Working P
机构信息
Department of Molecular Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
出版信息
Br J Cancer. 1995 Nov;72(5):1074-5. doi: 10.1038/bjc.1995.467.
Abstract
Weekly treatments with doxorubicin encapsulated in long circulating, sterically stabilised liposomes (DOX-SL) reduced the incidence of metastases from primary mammary carcinoma from 24 of 47 untreated mice to 3 of 23 treated mice. Toxic side-effects were limited to minor, transient weight losses.
摘要
每周使用包裹在长循环、空间稳定脂质体中的阿霉素（DOX-SL）进行治疗，可使原发性乳腺癌转移的发生率从47只未治疗小鼠中的24只降低至23只治疗小鼠中的3只。毒性副作用仅限于轻微的、短暂的体重减轻。
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