一项关于卡铂和长春瑞滨作为晚期乳腺癌二线治疗的II期研究。
A phase II study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer.
作者信息
Iaffaioli R V, Tortoriello A, Facchini G, Santangelo M, De Sena G, Gesue G, Bucci L, Scaramellino G, Anastasio E, Finizio A
机构信息
Istituto di Medicina Interna, Università di Cagliari, Italy.
出版信息
Br J Cancer. 1995 Nov;72(5):1256-8. doi: 10.1038/bjc.1995.496.
Abstract
Forty-one patients with advanced breast cancer were given carboplatin and vinorelbine as second-line therapy. Overall objective response rate was 46% (95% confidence interval 26-56%). Myelotoxicity was the most frequently observed toxic effect; grade III-IV leucopenia occurred in 46% of the patients. Our regimen is active as second-line chemotherapy for advanced breast cancer and warrants further evaluation.
摘要
41例晚期乳腺癌患者接受卡铂和长春瑞滨作为二线治疗。总体客观缓解率为46%（95%置信区间26 - 56%）。骨髓毒性是最常观察到的毒性反应；46%的患者发生III - IV级白细胞减少。我们的方案作为晚期乳腺癌的二线化疗是有效的，值得进一步评估。
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本文引用的文献
1
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Science. 1993 Jan 29;259(5095):631-2. doi: 10.1126/science.8430312.
2
Effective second line chemotherapy of advanced breast cancer with navelbine and mitomycin C.用去甲长春花碱和丝裂霉素C对晚期乳腺癌进行有效的二线化疗。
Breast Cancer Res Treat. 1993;26(1):49-53. doi: 10.1007/BF00682699.
3
Phase II evaluation of carboplatin and VP-16 for patients with metastatic breast cancer and only one prior chemotherapy regimen.卡铂和依托泊苷用于转移性乳腺癌且仅接受过一种既往化疗方案患者的II期评估。
Cancer. 1993 Aug 1;72(3):771-3. doi: 10.1002/1097-0142(19930801)72:3<771::aid-cncr2820720322>3.0.co;2-9.
4
Phase II trial of weekly intravenous vinorelbine in first-line advanced breast cancer chemotherapy.长春瑞滨每周静脉注射用于一线晚期乳腺癌化疗的II期试验。
J Clin Oncol. 1993 Jul;11(7):1245-52. doi: 10.1200/JCO.1993.11.7.1245.
5
Carboplatin in the treatment of advanced breast cancer: a phase II study using a pharmacokinetically guided dose schedule.
J Clin Oncol. 1993 Nov;11(11):2112-7. doi: 10.1200/JCO.1993.11.11.2112.
6
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J Clin Oncol. 1994 Feb;12(2):336-41. doi: 10.1200/JCO.1994.12.2.336.
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