对携带正常囊性纤维化跨膜传导调节因子cDNA的复制缺陷型重组腺病毒重复给药至囊性纤维化患者气道的评估。 - Suppr

Suppr

超能文献

Evaluation of repeat administration of a replication deficient, recombinant adenovirus containing the normal cystic fibrosis transmembrane conductance regulator cDNA to the airways of individuals with cystic fibrosis.

作者信息

Crystal R G, Mastrangeli A, Sanders A, Cooke J, King T, Gilbert F, Henschke C, Pascal W, Herena J, Harvey B G

机构信息

Rockefeller University Hospital, New York, New York 10021, USA.

出版信息

Hum Gene Ther. 1995 May;6(5):667-703. doi: 10.1089/hum.1995.6.5-667.

DOI:10.1089/hum.1995.6.5-667

PMID:7578402

Abstract

摘要

相似文献

Evaluation of repeat administration of a replication deficient, recombinant adenovirus containing the normal cystic fibrosis transmembrane conductance regulator cDNA to the airways of individuals with cystic fibrosis.对携带正常囊性纤维化跨膜传导调节因子cDNA的复制缺陷型重组腺病毒重复给药至囊性纤维化患者气道的评估。

Hum Gene Ther. 1995 May;6(5):667-703. doi: 10.1089/hum.1995.6.5-667.

A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung.一项针对囊性纤维化患者的1期研究，旨在评估单次给予一种携带正常囊性纤维化跨膜传导调节因子基因cDNA的复制缺陷型重组腺病毒在肺部的安全性、毒性和生物学疗效。

Hum Gene Ther. 1995 May;6(5):643-66. doi: 10.1089/hum.1995.6.5-643.

Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector.通过局部给予正常CFTR cDNA腺病毒基因转移载体对囊性纤维化个体鼻上皮电位差的改变。

Hum Gene Ther. 1995 Nov;6(11):1487-96. doi: 10.1089/hum.1995.6.11-1487.

[Aerosol administration of a replication defective recombinant adenovirus expressing normal human cDNA-CFTR in the respiratory tractus in patients with cystic fibrosis].[在囊性纤维化患者的呼吸道中雾化给予表达正常人cDNA-CFTR的复制缺陷型重组腺病毒]

C R Seances Soc Biol Fil. 1996;190(1):109-42.

Gene transfer to freshly isolated human respiratory epithelial cells in vitro using a replication-deficient adenovirus containing the human cystic fibrosis transmembrane conductance regulator cDNA.使用携带人囊性纤维化跨膜传导调节因子cDNA的复制缺陷型腺病毒，在体外将基因转移至新鲜分离的人呼吸道上皮细胞。

Hum Gene Ther. 1994 Mar;5(3):331-42. doi: 10.1089/hum.1994.5.3-331.

Gene therapy for cystic fibrosis utilizing a replication deficient recombinant adenovirus vector to deliver the human cystic fibrosis transmembrane conductance regulator cDNA to the airways. A phase I study.

Hum Gene Ther. 1994 Aug;5(8):1019-57. doi: 10.1089/hum.1994.5.8-1019.

Gene therapy for the respiratory manifestations of cystic fibrosis.针对囊性纤维化呼吸表现的基因治疗。

Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 2):S75-87. doi: 10.1164/ajrccm/151.3_Pt_2.S75.

Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. I. Methods, safety, and clinical implications.向囊性纤维化患者雾化吸入和肺叶给药重组腺病毒。I. 方法、安全性及临床意义。

Hum Gene Ther. 2001 Jul 20;12(11):1369-82. doi: 10.1089/104303401750298535.

A phase I study of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator gene to a lung segment of individuals with cystic fibrosis.一项关于腺病毒介导的人类囊性纤维化跨膜传导调节基因转移至囊性纤维化患者肺段的I期研究。

Hum Gene Ther. 1999 Dec 10;10(18):2973-85. doi: 10.1089/10430349950016384.

In vivo adenovirus-mediated transfer of human CFTR cDNA to rhesus monkey airway epithelium: efficacy, toxicity and safety.体内腺病毒介导的人囊性纤维化跨膜传导调节因子（CFTR）cDNA转移至恒河猴气道上皮：疗效、毒性和安全性

Gene Ther. 1994 Nov;1(6):385-94.

引用本文的文献

Viral Vectors, Animal Models, and Cellular Targets for Gene Therapy of Cystic Fibrosis Lung Disease.病毒载体、动物模型和囊性纤维化肺病基因治疗的细胞靶标。

Hum Gene Ther. 2020 May;31(9-10):524-537. doi: 10.1089/hum.2020.013. Epub 2020 Apr 15.

Update and Review: Cystic Fibrosis.更新与综述：囊性纤维化

J Genet Couns. 1999 Jun;8(3):137-62. doi: 10.1023/A:1022853822424.

Intratracheal delivery of CX3CL1-expressing mesenchymal stem cells to multiple lung tumors.向多个肺部肿瘤进行表达CX3CL1的间充质干细胞的气管内递送。

Mol Med. 2009 Sep-Oct;15(9-10):321-7. doi: 10.2119/molmed.2009.00059. Epub 2009 Jun 18.

Canine adenovirus vectors: an alternative for adenovirus-mediated gene transfer.犬腺病毒载体：腺病毒介导基因转移的一种替代方法。

J Virol. 2000 Jan;74(1):505-12. doi: 10.1128/jvi.74.1.505-512.2000.

Variability of human systemic humoral immune responses to adenovirus gene transfer vectors administered to different organs.人类对给予不同器官的腺病毒基因转移载体的全身体液免疫反应的变异性。

J Virol. 1999 Aug;73(8):6729-42. doi: 10.1128/JVI.73.8.6729-6742.1999.

Potential use of T cell receptor genes to modify hematopoietic stem cells for the gene therapy of cancer.T细胞受体基因在修饰造血干细胞用于癌症基因治疗方面的潜在应用。

Pathol Oncol Res. 1999;5(1):3-15. doi: 10.1053/paor.1999.0003.

A gene therapy approach to treatment of autoimmune disease.一种用于治疗自身免疫性疾病的基因治疗方法。

Immunol Res. 1998 Aug;18(1):15-26. doi: 10.1007/BF02786510.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验