应用针对牛病毒性腹泻病毒（BVDV）的抗体滴度作为检测牛群中持续感染BVDV的牛的一种方法。
Application of antibody titers against bovine viral diarrhea virus (BVDV) as a measure to detect herds with cattle persistently infected with BVDV.
作者信息
Houe H, Baker J C, Maes R K, Ruegg P L, Lloyd J W
机构信息
Department of Clinical Studies, The Royal Veterinary and Agricultural University, Frederikberg, Denmark.
出版信息
J Vet Diagn Invest. 1995 Jul;7(3):327-32. doi: 10.1177/104063879500700305.
Based on the distribution of antibody titers against bovine viral diarrhea virus (BVDV) in 10 Michigan dairy herds, it was calculated that screening of 5 young stock for BVDV antibody titer could be used to distinguish herds with persistently infected (PI) animals from herds without such animals. The herds were selected to represent 3 different herd categories: A, herds without use of vaccination and without PI animals (5 herds); B, herds with use of killed vaccine but no PI animals (2 herds); C, herds with use of killed vaccine and presence of PI animals (3 herds). The animals were described as having high antibody titers (> or = 128) or low antibody titers (< or = 64). For animals from 9 to 18 months of age, the probability of obtaining at least 3 animals with high titers among a screening sample of 5 animals was calculated as < 0.001 for all herds in category A, < 0.01 for the 2 herds in category B, and > 0.99 for all herds in category C. Thus, among herds in this study, by categorizing 9-18-month-old animals as having high titers (> or = 128) or low titers (< or = 64), herds with PI cattle could be distinguished from other herds by testing only 5 animals.
根据密歇根州10个奶牛场中针对牛病毒性腹泻病毒（BVDV）的抗体滴度分布情况，经计算得出，对5头青年牛进行BVDV抗体滴度筛查，可用于区分存在持续性感染（PI）动物的牛群和不存在此类动物的牛群。这些牛群被选取以代表3种不同的牛群类别：A类，未使用疫苗且不存在PI动物的牛群（5个牛群）；B类，使用灭活疫苗但不存在PI动物的牛群（2个牛群）；C类，使用灭活疫苗且存在PI动物的牛群（3个牛群）。这些动物被描述为具有高抗体滴度（≥128）或低抗体滴度（≤64）。对于9至18月龄的动物，在5头动物的筛查样本中获得至少3头高滴度动物的概率，计算得出A类所有牛群均<0.001，B类的2个牛群<0.01，C类所有牛群>0.99。因此，在本研究的牛群中，通过将9至18月龄的动物分类为高滴度（≥128）或低滴度（≤64），仅检测5头动物就能将存在PI牛的牛群与其他牛群区分开来。
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