Zetterqvist L, Anneroth G, Nordenram A, Wroblewski R
Department of Oral Surgery, Karolinska Institute, Stockholm, Sweden.
Clin Oral Implants Res. 1995 Jun;6(2):104-13. doi: 10.1034/j.1600-0501.1995.060206.x.
In 8 monkeys both the maxillary lateral incisors were extracted. In the 16 extraction sites an Al2O3-ceramic dental implant (Frialit) was immediately inserted. Eight implants were submerged under the oral mucosa and the other 8 were allowed to penetrate through the mucosa during the observation period. None of the implants was loaded during the observation periods. After experimental periods of 1, 2, 4 and 8 months, the interface region between the implant and bone was examined using scanning-electron microscopy, X-ray microanalysis, back scatter, microradiography and light microscopy. The results showed that osseointegration of Al2O3-ceramic dental implant was obtained. The newly formed bone around the implant filled exactly the contours of the implant. Newly formed bone had a mineral content and a phosphorus-to-calcium ratio similar to that of the adjacent older mature jaw bone. There were no differences in the osseointegration rate between the submerged and the nonsubmerged implants. No leakage of aluminium from the implant could be detected in the bone.
在8只猴子身上拔除了双侧上颌侧切牙。在16个拔牙位点立即植入了Al2O3陶瓷牙种植体（Frialit）。在观察期内，8枚种植体被埋置于口腔黏膜下，另外8枚则任其穿透黏膜。在观察期内，所有种植体均未加载负荷。在1、2、4和8个月的实验期后，使用扫描电子显微镜、X射线微分析、背散射、显微放射照相术和光学显微镜检查种植体与骨之间的界面区域。结果表明，Al2O3陶瓷牙种植体实现了骨结合。种植体周围新形成的骨精确地填充了种植体的轮廓。新形成的骨的矿物质含量以及磷钙比与相邻的较老成熟颌骨相似。埋置式种植体和非埋置式种植体在骨结合率上没有差异。在骨中未检测到种植体有铝泄漏。
