Mattout P, Nowzari H, Mattout C
Department of Periodontology, University of Southern California, Los Angeles, USA.
Clin Oral Implants Res. 1995 Sep;6(3):189-95. doi: 10.1034/j.1600-0501.1995.060308.x.
This investigation evaluated guided bone regeneration with a polytetrafluoroethylene barrier membrane at exposed parts of Brånemark dental implants with and without concomitant use of decalcified freeze-dried bone allograft. Density of the regenerated tissue was also determined using a No. 23 probe at a pressure of 25 g and was graded from 1 to 5. The higher index was associated with a higher resistance of newly formed tissue to the pressure of the probe. In 19 patients, 23 defects were treated by barrier membrane alone and 11 defects by bone allograft with barrier membrane. The width and the depth of the defects were determined at the time of the implant placement and at the second-stage implant surgery. When success was defined as 0 mm of residual defect, the mean success rate was 68% for the membrane group and 90% for the membrane group with bone allograft, with no statistically significant difference between the two treatment groups. The two groups did not demonstrate a significant difference in median density index. There was a significant positive relationship between time of membrane coverage and density index. A density index of 4 was only recorded after 7 months of membrane coverage. The present findings suggest beneficial clinical effect with the use of membrane alone and freeze-dried bone allograft with membrane for guided bone regeneration. This study proposed the use of a novel density index for clinical evaluation of regenerated tissue.
本研究评估了在有或无同时使用脱钙冻干骨同种异体移植物的情况下，聚四氟乙烯屏障膜对Brånemark牙种植体暴露部位进行引导骨再生的效果。还使用23号探针在25克压力下测定再生组织的密度，并将其分为1至5级。指数越高，新形成的组织对探针压力的抵抗力越高。19例患者中，23处缺损仅用屏障膜治疗，11处缺损采用骨同种异体移植物联合屏障膜治疗。在种植体植入时和二期种植手术时测定缺损的宽度和深度。当成功定义为残余缺损为0毫米时，单纯使用屏障膜组的平均成功率为68%，使用骨同种异体移植物联合屏障膜组的平均成功率为90%，两组之间无统计学显著差异。两组在中位密度指数上无显著差异。屏障膜覆盖时间与密度指数之间存在显著正相关。仅在屏障膜覆盖7个月后记录到密度指数为4。目前的研究结果表明，单纯使用屏障膜以及使用冻干骨同种异体移植物联合屏障膜进行引导骨再生具有有益的临床效果。本研究提出使用一种新的密度指数对再生组织进行临床评估。
