Sanders L R
Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, TX, USA.
J Am Soc Nephrol. 1995 Jun;5(12):2020-3. doi: 10.1681/ASN.V5122020.
Nonsteroidal anti-inflammatory drugs predispose to acute renal failure in conditions associated with decreased RBF. Such conditions include advanced age, hypertension, chronic renal insufficiency, diuretic use, and any condition decreasing effective circulating volume. Strenuous exercise also causes marked reductions in RBF. The patient discussed developed severe acute renal failure after strenuous exercise and therapeutic doses of ibuprofen and hydrochlorothiazide-triamterene. Urinalysis showed a nephritic sediment with red blood cell casts. Renal biopsy showed acute tubular necrosis and arteriolar nephrosclerosis. Although exercise-associated acute renal failure is uncommon, susceptible patients with exercise-induced renal ischemia and prostaglandin inhibition may develop this complication.
在肾血流量（RBF）降低的情况下，非甾体类抗炎药易引发急性肾衰竭。此类情况包括高龄、高血压、慢性肾功能不全、使用利尿剂以及任何导致有效循环血容量减少的病症。剧烈运动也会使肾血流量显著降低。文中所讨论的患者在剧烈运动以及服用治疗剂量的布洛芬和氢氯噻嗪 - 氨苯蝶啶后，出现了严重的急性肾衰竭。尿液分析显示为肾炎性沉渣伴红细胞管型。肾活检显示急性肾小管坏死和小动脉性肾硬化。尽管运动相关性急性肾衰竭并不常见，但具有运动诱导性肾缺血和前列腺素抑制作用的易感患者可能会发生这种并发症。
