Serum lipid and glucose concentrations with a propofol infusion for cardiac surgery.

OBJECTIVE

To document changes in serum lipids and glucose with a propofol infusion technique for cardiac surgery.

DESIGN

Prospective cohort.

SETTING

University teaching hospital.

PARTICIPANTS

22 elective cardiac surgical patients.

INTERVENTIONS

Frequent venous blood sampling.

MEASUREMENTS AND MAIN RESULTS

Serum lipids and glucose were measured at 10 time periods perioperatively, from preinduction until 4 hours post-cardiopulmonary bypass. Plasma propofol concentrations were also measured in 10 of these patients. There was a significant increase in glucose (P < 0.0005) and decreases in cholesterol (P < 0.0005), high-density lipoprotein (P = 0.004), and low-density lipoprotein (P < 0.0005); there was no significant change in triglycerides (P = 0.39). The propofol infusion resulted in acceptable plasma levels throughout the procedure and allowed early extubation in the intensive care unit, after a mean (SD) of 7.14 (5.9) hours. There was a strong correlation between triglyceride and propofol levels at most time periods (r = 0.38 to 0.98).

CONCLUSIONS

This study demonstrates that a propofol infusion technique does not result in elevation of serum lipids and supports its increased popularity in maintenance of anesthesia for cardiac surgery.