Leone L, Comandone A, Oliva C, Bussi P, Goffredo F, Bretti S, Bumma C
Laboratorio Analisi, Ospedale Regina Margherita, Torino, Italy.
Anticancer Drugs. 1995 Aug;6(4):604-7. doi: 10.1097/00001813-199508000-00015.
The stability of ifosfamide in Ringer lactate buffer solution either alone or mixed with mesna at 37 degrees C for a 7-day period was analyzed by HPLC. This study was performed to investigate the feasibility of continuous infusion of ifosfamide by a multiday pump in order to reduce the toxicity and to increase the production of active alkylating metabolites of the parent drug. The total decay of ifosfamide activity did not exceed 3.2% at day 7. We conclude that ifosfamide can be safely delivered in a 7-day infusion with no significant loss of activity.
通过高效液相色谱法（HPLC）分析了异环磷酰胺在乳酸林格氏缓冲溶液中单独存在或与美司钠混合时于37℃下7天内的稳定性。进行本研究是为了探讨使用多日泵持续输注异环磷酰胺以降低毒性并增加母体药物活性烷基化代谢物产量的可行性。在第7天，异环磷酰胺活性的总衰减不超过3.2%。我们得出结论，异环磷酰胺可以在7天的输注过程中安全给药，且活性无显著损失。
