设计新颖序列以匹配给定折叠结构的理论方法。

Theoretical approaches to designing novel sequences to fit a given fold.

作者信息

Jones D T

机构信息

Department of Biochemistry and Molecular Biology, University College, London, UK.

出版信息

Curr Opin Biotechnol. 1995 Aug;6(4):452-9. doi: 10.1016/0958-1669(95)80075-1.

DOI:10.1016/0958-1669(95)80075-1

PMID:7579656

Abstract

One of the major goals of molecular biology is to understand how protein chains fold into a unique three-dimensional structure. Given this knowledge, perhaps the most exciting prospect will be the possibility of designing new proteins to perform designated tasks. The eventual pinnacle of protein engineering will be the fully automated design of a protein with novel structure and function. Achievement of this aim lies far in the future, although some early progress has been made recently.

摘要

分子生物学的主要目标之一是了解蛋白质链如何折叠成独特的三维结构。有了这方面的知识，或许最令人兴奋的前景将是设计新蛋白质以执行特定任务的可能性。蛋白质工程的最终巅峰将是对具有新颖结构和功能的蛋白质进行全自动设计。尽管最近已经取得了一些早期进展，但实现这一目标仍遥遥无期。