Badache A, Lehmann S, Kuchler-Bopp S, Hand N, Zanetta J P
Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires CNRS UPR 416, Centre de Neurochimie, Strasbourg, France.
Glycobiology. 1995 Jun;5(4):371-83. doi: 10.1093/glycob/5.4.371.
The proliferation of Schwann cells (the myelinating cells of the peripheral nervous system) is stimulated by the contact with axonal membranes. It is suggested that the endogenous carbohydrate-binding protein (lectin) cerebellar soluble lectin (CSL) bound to ligands at the surface of axonal preparations is mitogenic for Schwann cells. Both autocrine and axon-stimulated Schwann cell proliferations seem to be dependent on the presence of CSL and its ligands at the Schwann cell surface, as suggested by the effects of N-glycosylation inhibitors and anti-CSL Fab fragments. These data suggest that CSL regulates Schwann cell proliferation by clustering of a few glycoprotein ligands at the cell surface, consequently modulating phosphorylations.
施万细胞（周围神经系统的髓鞘形成细胞）的增殖受到与轴突膜接触的刺激。有人提出，与轴突制剂表面配体结合的内源性碳水化合物结合蛋白（凝集素）小脑可溶性凝集素（CSL）对施万细胞具有促有丝分裂作用。N-糖基化抑制剂和抗CSL Fab片段的作用表明，自分泌和轴突刺激的施万细胞增殖似乎都依赖于施万细胞表面CSL及其配体的存在。这些数据表明，CSL通过在细胞表面聚集一些糖蛋白配体来调节施万细胞增殖，从而调节磷酸化作用。
