Schultz M, Kunz H
Institut für Organische Chemie, Johannes Gutenberg-Universität, Mainz, Germany.
EXS. 1995;73:201-28. doi: 10.1007/978-3-0348-9061-8_10.
Progress recently made in the synthesis of biologically relevant N- and O-glycopeptides is illustrated by examples. In this context, developments in the preparation of complex saccharide side chains and in the subsequent coupling to peptide portions is described. Special emphasis is given to the synthesis of Lewis antigen-type structures. Furthermore, modern methods in solid phase peptide syntheses utilizing glycosylated building blocks are presented. Recent advances in glycopeptide syntheses employing enzymatic methods in deprotection steps as well as in peptide/saccharide chain elongation are reported.
文中通过实例展示了近期在生物相关N-糖肽和O-糖肽合成方面取得的进展。在此背景下，描述了复杂糖侧链制备及后续与肽段偶联的进展。特别强调了Lewis抗原型结构的合成。此外，还介绍了利用糖基化构建块进行固相肽合成的现代方法。报道了在脱保护步骤以及肽/糖链延长中采用酶法的糖肽合成的最新进展。
