Wöhrmann T, Geist C, Schneider J, Matthiesen T, Zwingenberger K
Department of Toxicology and Pathology, Gruenenthal Research Centre, Aachen, Germany.
Exp Toxicol Pathol. 1995 May;47(2-3):167-72. doi: 10.1016/S0940-2993(11)80309-X.
A local Shwartzman response was elicited in rabbits by an intradermal injection of the Salmonella typhosa endotoxin lipopolysaccharide (LPS) followed 24 hours later by an intravenous challenge injection with zymosan. After the intravenous challenge, necrotizing vasculitis developed in the prepared skin sites which was characterized by microthrombi, accumulation of neutrophil granulocytes, fibrin deposition and extravasation of red blood cells. Evans' blue extravasation into the altered tissue was significantly reduced, and histologically, the intensity of the Shwartzman reaction in the skin was reduced by pretreatment with thalidomide and dexamethasone. The mechanism of reduction of an LPS-induced local Shwartzman reaction by thalidomide is discussed.
通过皮内注射伤寒沙门氏菌内毒素脂多糖（LPS）在兔子身上引发局部施瓦茨曼反应，24小时后静脉注射酵母聚糖进行激发注射。静脉注射激发后，在预先准备的皮肤部位出现坏死性血管炎，其特征为微血栓形成、中性粒细胞聚集、纤维蛋白沉积和红细胞外渗。伊文思蓝向病变组织的外渗显著减少，并且在组织学上，沙利度胺和地塞米松预处理可降低皮肤中施瓦茨曼反应的强度。本文讨论了沙利度胺减轻LPS诱导的局部施瓦茨曼反应的机制。
