Bergstein J M
Am J Pathol. 1977 Jan;86(1):117-22.
Four albino rabbits received two intradermal injections of endotoxin followed in 24 hours by an intravenous injection of endotoxin. All animals developed the local Shwartzman reaction, characterized by hemorrhagic necrosis over each intradermal injection site. Light microscopy of the Shwartzman lesion showed intense inflammation and vascular thrombosis. Frozen sections of the skin lesion revealed marked vascular deposition of fibrin with lesser amounts of IgG, IgM, C3, and albumin. Light microscopy was normal and immunofluorescence was negative in skin obtained prior to the initial injection of endotoxin and skin adjacent to the Shwartzman lesion. These findings suggest nonspecific trapping of serum proteins within vascular thrombi and indicate that immune mechanisms may not play a role in the pathogenesis of the local Shwartzman reaction.
四只白化兔接受了两次皮内注射内毒素，24小时后再进行一次静脉注射内毒素。所有动物均出现局部施瓦茨曼反应，其特征为每个皮内注射部位出现出血性坏死。施瓦茨曼损伤的光镜检查显示有强烈炎症和血管血栓形成。皮肤损伤的冰冻切片显示纤维蛋白在血管中有明显沉积，同时还有少量的IgG、IgM、C3和白蛋白。在首次注射内毒素之前获取的皮肤以及与施瓦茨曼损伤相邻的皮肤，其光镜检查正常，免疫荧光检查为阴性。这些发现提示血清蛋白在血管血栓内的非特异性截留，并表明免疫机制可能在局部施瓦茨曼反应的发病机制中不起作用。
