Masand P, Murray G B, Pickett P
Psychiatric Consult Service, Massachusetts General Hospital, Boston, USA.
J Neuropsychiatry Clin Neurosci. 1991 Winter;3(1):23-7. doi: 10.1176/jnp.3.1.23.
The hospital charts of 17 patients with post-stroke depression who were treated with either dextroamphetamine or methylphenidate during a 5-year period at the Massachusetts General Hospital were examined. Eighty-two percent of the patients showed improvement after psychostimulant treatment. Forty-seven percent of all patients showed marked or moderate improvement in depressive symptoms. The authors saw no significant differences in efficacy between the two psychostimulants or across the diagnostic categories for depression. Patients improved quickly, usually within the first 2 days of treatment. Adverse reactions necessitating the termination of psychostimulant treatment occurred in three patients. Anorexia was not observed as a side effect of either dextroamphetamine or methylphenidate treatment. Psychostimulants appear to be a safe and rapidly effective alternative to tricyclic antidepressants in inpatients with post-stroke depression.
对17例中风后抑郁症患者的医院病历进行了检查，这些患者在5年期间于马萨诸塞州综合医院接受了右旋苯丙胺或哌醋甲酯治疗。82%的患者在接受精神振奋剂治疗后病情有所改善。所有患者中有47%的患者抑郁症状有显著或中度改善。作者发现两种精神振奋剂之间或不同抑郁症诊断类别之间在疗效上没有显著差异。患者改善迅速，通常在治疗的头两天内。有3例患者出现了需要终止精神振奋剂治疗的不良反应。未观察到厌食是右旋苯丙胺或哌醋甲酯治疗的副作用。在中风后抑郁症住院患者中，精神振奋剂似乎是三环类抗抑郁药的一种安全且起效迅速的替代药物。
