Pullicino P, Galizia A C, Azzopardi C
University of Malta, St. Luke's Hospital, Gwardamangia, Malta.
J Neuropsychiatry Clin Neurosci. 1991 Winter;3(1):75-7. doi: 10.1176/jnp.3.1.75.
Two young women with no risk factors for cerebrovascular disease developed hyperpyrexia, rigidity, and autonomic features while taking neuroleptic agents. The first presented with increasing rigidity, profuse diaphoresis and dehydration, and a right hemiparesis, and computed tomography (CT) showed a left striato-capsular infarction. The second became unresponsive following severe hypoxia and was found to have left-sided pyramidal signs three days later. Hemoconcentration and hypoxemia predispose to cerebral ischemic injury in the neuroleptic malignant syndrome and should be avoided as much as possible.
两名无脑血管疾病危险因素的年轻女性在服用抗精神病药物时出现高热、强直及自主神经症状。第一名患者表现为逐渐加重的强直、大量出汗和脱水，以及右侧偏瘫，计算机断层扫描（CT）显示左侧纹状体-壳核梗死。第二名患者在严重缺氧后失去反应，三天后发现有左侧锥体束征。血液浓缩和低氧血症易导致抗精神病药恶性综合征中的脑缺血损伤，应尽可能避免。
