Maruff P, Malone V, McArthur-Jackson C, Mulhall B, Benson E, Currie J
Neurophysiology and Neurovisual Research Unit, Mental Health Research Institute of Victoria, Parkville, Australia.
J Neuropsychiatry Clin Neurosci. 1995 Summer;7(3):325-33. doi: 10.1176/jnp.7.3.325.
Covert orienting of visuospatial attention (COVAT) was examined in 88 homosexual or bisexual men: 12 with mild HIV-associated dementia complex (ADC), 30 neurologically intact with AIDS (NI-AIDS), 23 asymptomatic HIV+ (HIV+ASX), and 23 HIV-negative control subjects. In mild ADC, COVAT was normal for spatial but impaired for nonspatial cues; 17% of NI-AIDS and HIV+ASX subjects had similar COVAT impairment patterns and also showed cognitive deficits. HIV+ subjects with normal COVAT showed normal cognitive performance. Impairment of nonspatial attentional processing in the ADC subjects and subgroups of the neurologically intact HIV+ subjects may reflect early subcortical dysfunction caused by HIV infection. COVAT assessment may be sensitive for detection of early subclinical neurological impairment in HIV infection.
对88名同性恋或双性恋男性进行了视觉空间注意的隐蔽定向（COVAT）检测：12名患有轻度HIV相关痴呆综合征（ADC），30名艾滋病患者神经功能正常（NI-AIDS），23名无症状HIV阳性（HIV+ASX），以及23名HIV阴性对照受试者。在轻度ADC中，COVAT在空间线索方面正常，但在非空间线索方面受损；17%的NI-AIDS和HIV+ASX受试者有类似的COVAT损伤模式，并且也表现出认知缺陷。COVAT正常的HIV+受试者表现出正常的认知能力。ADC受试者以及神经功能正常的HIV+受试者亚组中非空间注意力加工的损伤可能反映了HIV感染引起的早期皮质下功能障碍。COVAT评估对于检测HIV感染早期亚临床神经损伤可能很敏感。
