Howland E W, Wakai R T, Mjaanes B A, Balog J P, Cleeland C S
Department of Neurology, University of Wisconsin-Madison 53792, USA.
Brain Res Cogn Brain Res. 1995 Jul;2(3):165-72. doi: 10.1016/0926-6410(95)90005-5.
Painful intracutaneous electric finger shock was delivered to the fifth digit of the non-dominant hand of five healthy volunteers. Whole head evoked magnetic field maps were collected and cortical localizations were calculated using local sphere equivalent current dipole fits. MRI scans were used to identify the anatomical structures where magnetic field sources were located. Anatomically, sources were identified bilaterally in the primary somatosensory region and SII-Insula regions. Additionally, frontal operculum sources were observed contralaterally in two subjects. Temporally, an initial contralateral SI activation at 40-60 ms was followed by several SII-Insula responses over the next several hundred milliseconds (ms). These SII-Insula responses were often interspersed with additional activations of the SI region. These later responses were observed in both hemispheres.
对五名健康志愿者非优势手的小指进行疼痛性皮内电刺激。采集全脑诱发磁场图，并使用局部球等效电流偶极拟合计算皮质定位。利用磁共振成像扫描来识别磁场源所在的解剖结构。从解剖学上看，在双侧的初级体感区和SII-岛叶区发现了磁场源。此外，在两名受试者中对侧观察到额盖区的磁场源。在时间上，最初在40-60毫秒时对侧体感皮层（SI）激活，随后在接下来的几百毫秒内出现几次SII-岛叶反应。这些SII-岛叶反应常常夹杂着体感皮层（SI）区域的额外激活。在两个半球均观察到了这些较晚出现的反应。
