Abelson H T, Gorka C, Beardsley G P
Blood. 1979 Jan;53(1):116-21.
Normal human platelets were shown to contain the enzyme dihydropteridine reductase. The enzyme was not found in a variety of other cells of hematogenous origin. Partial purification and kinetic and physical data indicated that the platelet enzyme is similar to that previously characterized from liver. Dihydropteridine reductase is important for the regeneration of tetrahydrobiopterin, a required cofactor in hydroxylation reactions involved in biogenic amine formation. The presence of the enzyme may indicate that some synthesis de novo of serotonin and/or catecholamines occurs in platelets, as opposed to a purely storage and transport function. In addition, screening for hyperphenylalaninemia due to dihydropteridine reductase deficiency may become feasible by assaying platelets for enzyme activity.
已证实正常人血小板含有二氢蝶啶还原酶。在多种造血源性其他细胞中未发现该酶。部分纯化以及动力学和物理数据表明，血小板中的该酶与先前从肝脏中鉴定出的酶相似。二氢蝶啶还原酶对于四氢生物蝶呤的再生很重要，四氢生物蝶呤是生物胺形成过程中羟化反应所需的一种辅助因子。该酶的存在可能表明血小板中会发生一些5-羟色胺和/或儿茶酚胺的从头合成，而非仅仅具有储存和运输功能。此外，通过检测血小板中的酶活性来筛查因二氢蝶啶还原酶缺乏导致的高苯丙氨酸血症可能变得可行。
