Mazzucotelli J P, Bertrand P C, Loisance D Y
Department of Surgical Research, Henri Mondor Hospital, Creteil, France.
J Heart Valve Dis. 1995 Jul;4(4):407-13.
From 1983 to 1992, 366 patients received 407 Mitroflow pericardial bioprostheses at our institution. Mean age was 62 +/- 14 years (range: 15-86 years). There were 229 isolated aortic valve replacements (AVR), 96 isolated mitral valve replacements (MVR), 39 double mitral and aortic valve replacements (DVR) and four tricuspid replacements. Mean follow up was 6 +/- 2.33 years ranging from 1.67 to 10.9 years. Total follow up was 1791 patient-years. Overall survival was 77.2 +/- 2.2% at five and 56.2 +/- 6.4% at 10 years. It was 74 +/- 3% and 56.2 +/- 5.3% after AVR, 78.3 +/- 4.4% and 55.7 +/- 8.8% after MVR, 81 +/- 6.4% and 36.6 +/- 16.5% after DVR at five and 10 years, respectively. Freedom from structural valve deterioration (SVD) was 95 +/- 1.2% and 36.7 +/- 8.1% at five and 10 years for all valves, 96.9 +/- 1.3% and 39.2 +/- 9.8% for AVR, 91.7 +/- 3.2% and 36.4 +/- 10% for MVR. There was no difference in freedom from SVD between AVR and MVR. The freedom from SVD in patients older than 70 years of age was 100% and 93.9 +/- 5.8% at five and 10 years, respectively. Freedom from reoperation was 94.7 +/- 1.37% and 28.36 +/- 7.5% at five and 10 years for all valves, 96.2 +/- 1.5% and 38.6 +/- 9.7% for AVR, 91.7 +/- 3.2% and 36.4 +/- 10% for MVR. The denaturation process did not lead to acute hemodynamic deterioration. Pathologic findings were cuspal tears (one or more) associated with structural tissue changes.(ABSTRACT TRUNCATED AT 250 WORDS)
1983年至1992年期间，我院366例患者接受了407枚Mitroflow心包生物瓣膜置换。平均年龄为62±14岁（范围：15 - 86岁）。其中单纯主动脉瓣置换（AVR）229例，单纯二尖瓣置换（MVR）96例，二尖瓣和主动脉瓣双瓣置换（DVR）39例，三尖瓣置换4例。平均随访时间为6±2.33年，范围为1.67至10.9年。总随访时间为1791患者年。5年总生存率为77.2±2.2%，10年为56.2±6.4%。AVR术后5年和10年分别为74±3%和56.2±5.3%，MVR术后分别为78.3±4.4%和55.7±8.8%，DVR术后5年和10年分别为81±6.4%和36.6±16.5%。所有瓣膜5年和10年无结构性瓣膜退变（SVD）的发生率分别为95±1.2%和36.7±8.1%，AVR分别为96.9±1.3%和39.2±9.8%，MVR分别为91.7±3.2%和36.4±10%。AVR和MVR在无SVD发生率方面无差异。70岁以上患者5年和10年无SVD发生率分别为100%和93.9±5.8%。所有瓣膜5年和10年再次手术率分别为94.7±1.37%和28.36±7.5%，AVR分别为96.2±1.5%和38.6±9.7%，MVR分别为91.7±3.2%和36.4±10%。变性过程未导致急性血流动力学恶化。病理结果为伴有结构组织改变的瓣叶撕裂（一个或多个）。（摘要截选至250字）
