Biffl W L, Moore E E, Moore F A
Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Centre, Colorado 80204, USA.
Br J Hosp Med. 1995;54(4):134-8.
Laboratory studies suggest that the postischaemic gut serves as a priming bed for circulating neutrophils that provoke multiple organ failure. Platelet-activating factor, generated by phospholipase A2, appears to be active in priming neutrophils in the gut. Interleukin-6 also appears to be elaborated by the postischaemic gut, but may be even more important in distant organs via promoting neutrophil-mediated organ dysfunction.
实验室研究表明，缺血后的肠道是循环中性粒细胞的启动场所，这些中性粒细胞会引发多器官功能衰竭。由磷脂酶A2产生的血小板激活因子似乎在启动肠道中的中性粒细胞方面具有活性。白细胞介素-6似乎也由缺血后的肠道产生，但它可能通过促进中性粒细胞介导的器官功能障碍，在远处器官中发挥更重要的作用。
