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2
Effects of the calcium channel facilitator, CGP 28,392, on different modes of contraction in smooth muscle of rabbit and rat aortae and guinea-pig taenia caeci.钙通道促进剂CGP 28392对兔和大鼠主动脉及豚鼠盲肠带平滑肌不同收缩模式的影响
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4
Effect of UK-84149 on voltage-activated calcium currents of single smooth muscle cells from guinea-pig and rabbit jejunum and rabbit coronary artery.UK-84149对豚鼠和兔空肠以及兔冠状动脉单个平滑肌细胞电压激活钙电流的影响。
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Actions of a new Ca2+ channel antagonist, CD832, on two types of Ca2+ channels in smooth muscle.新型钙离子通道拮抗剂CD832对平滑肌中两种类型钙离子通道的作用
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Nitrosonifedipine ameliorates the progression of type 2 diabetic nephropathy by exerting antioxidative effects.亚硝基硝苯地平通过发挥抗氧化作用改善2型糖尿病肾病的进展。
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Nitrosonifedipine ameliorates angiotensin II-induced vascular remodeling via antioxidative effects.硝普钠通过抗氧化作用改善血管紧张素Ⅱ诱导的血管重构。
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Modulation by dihydropyridine-type calcium channel antagonists of cytokine-inducible gene expression in vascular smooth muscle cells.二氢吡啶类钙通道拮抗剂对血管平滑肌细胞中细胞因子诱导基因表达的调节作用
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本文引用的文献

1
Some quantitative uses of drug antagonists.药物拮抗剂的一些定量应用。
Br J Pharmacol Chemother. 1959 Mar;14(1):48-58. doi: 10.1111/j.1476-5381.1959.tb00928.x.
2
Effects of phenylephrine on membrane currents in single smooth muscle cells of taenia caeci.
Methods Find Exp Clin Pharmacol. 1994 Jun;16(5):337-46.
3
Protection against lipid peroxidation by a microsomal glutathione-dependent labile factor.微粒体谷胱甘肽依赖性不稳定因子对脂质过氧化的保护作用。
FEBS Lett. 1983 Aug 8;159(1-2):24-8. doi: 10.1016/0014-5793(83)80409-8.
4
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.用于从细胞和无细胞膜片进行高分辨率电流记录的改进膜片钳技术。
Pflugers Arch. 1981 Aug;391(2):85-100. doi: 10.1007/BF00656997.
5
Synchronization and conduction of excitation in the rat aorta.
Am J Physiol. 1969 Aug;217(2):376-82. doi: 10.1152/ajplegacy.1969.217.2.376.
6
Papaverine blockade of the calcium action in depolarized taenia coli of the guinea-pig.
Experientia. 1971 Jul;27(7):815-6. doi: 10.1007/BF02136883.
7
Spectrophotometric study of the photodecomposition kinetics of nifedipine.硝苯地平光分解动力学的分光光度研究
J Pharm Pharmacol. 1987 Dec;39(12):1044-6. doi: 10.1111/j.2042-7158.1987.tb03160.x.
8
The role of calcium antagonists in the treatment of myocardial ischemia.钙拮抗剂在心肌缺血治疗中的作用。
Am Heart J. 1989 Nov;118(5 Pt 2):1093-6; discussion 1096-7. doi: 10.1016/0002-8703(89)90832-6.
9
Lipid peroxidation of phosphatidylcholine liposomes depressed by the calcium channel blockers nifedipine and verapamil and by the antiarrhythmic-antihypoxic drug stobadine.
Biochim Biophys Acta. 1989 Jun 28;1003(3):238-45. doi: 10.1016/0005-2760(89)90228-2.
10
Comparative antioxidant activities of propranolol, nifedipine, verapamil, and diltiazem against sarcolemmal membrane lipid peroxidation.
Circ Res. 1990 May;66(5):1449-52. doi: 10.1161/01.res.66.5.1449.

强效抗氧化剂光照硝苯地平对肠道和血管平滑肌的作用。

Effect of illuminated nifedipine, a potent antioxidant, on intestinal and vascular smooth muscles.

作者信息

Bauer V, Rekalov V V, Juránek I, Gergel D, Bohov P

机构信息

Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.

出版信息

Br J Pharmacol. 1995 Jul;115(6):871-4. doi: 10.1111/j.1476-5381.1995.tb15890.x.

DOI:10.1111/j.1476-5381.1995.tb15890.x
PMID:7582513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1909028/
Abstract
  1. The effects of nifedipine (Nif) and its illuminated nitroso product nitrosopine (NTP) were investigated on lipid peroxidation, KCl elevated smooth muscle tension, and ionic currents of single smooth muscle cells. 2. Illumination of Nif at 400-700 nm within 24-48 h changed it completely to a potent antioxidant, NTP. 3. Nif relaxed the KCl-induced contractions of guinea-pig taenia caeci and rat aorta and reduced the amplitude of the evoked inward Ca2+ current of taenia caeci cells in a concentration-dependent manner. NTP (up to 100 microM) was ineffective in this respect. Pretreatment by NTP (10 microM) did not affect the actions of Nif. 4. The evidence suggests that NTP, generated by day-light illumination from Nif, exerts antioxidant activity but is devoid of voltage-dependent Ca2+ channel (VDC) blocking property and does not interfere with the action of Nif on the smooth muscle cell membrane VDC.
摘要
  1. 研究了硝苯地平（Nif）及其光照亚硝基产物亚硝基平（NTP）对脂质过氧化、氯化钾升高的平滑肌张力以及单个平滑肌细胞离子电流的影响。2. 在24 - 48小时内，硝苯地平在400 - 700纳米光照下完全转变为一种强效抗氧化剂——亚硝基平。3. 硝苯地平可舒张氯化钾诱导的豚鼠盲肠带和大鼠主动脉收缩，并以浓度依赖方式降低盲肠带细胞诱发的内向钙电流幅度。在这方面，亚硝基平（高达100微摩尔）无效。亚硝基平（10微摩尔）预处理不影响硝苯地平的作用。4. 证据表明，由硝苯地平经日光照射产生的亚硝基平具有抗氧化活性，但不具有电压依赖性钙通道（VDC）阻断特性，且不干扰硝苯地平对平滑肌细胞膜VDC的作用。