硝酸甘油诱导对硝酸甘油具有血管耐受性的大鼠离体工作心脏缺血心肌的直接保护作用。
Nitroglycerin-induced direct protection of the ischaemic myocardium in isolated working hearts of rats with vascular tolerance to nitroglycerin.
作者信息
Ferdinandy P, Szilvássy Z, Csont T, Csonka C, Nagy E, Koltai M, Dux L
机构信息
Dept of Biochemistry, Szent-Györgyi University, Szeged, Hungary.
出版信息
Br J Pharmacol. 1995 Aug;115(7):1129-31. doi: 10.1111/j.1476-5381.1995.tb15014.x.
Abstract
We investigated whether nitroglycerin (NTG) was able to produce an anti-ischaemic effect in isolated working hearts of rats with vascular tolerance to NTG. Hearts isolated from tolerant and non-tolerant rats were subjected to 10 min coronary occlusion in the presence of 10(-7) M NTG and/or its solvent. NTG alleviated ischaemia-induced deterioration of cardiac function and decreased lactate dehydrogenase release whilst having no effect on coronary flow nor the area of the ischaemic zone both in hearts isolated from NTG-tolerant and non-tolerant rats. The magnitude of the effect was similar in the two groups. These results suggest that the anti-ischaemic effect of NTG involves direct myocardial mechanisms independent of its vascular action and that vascular tolerance to NTG does not affect this direct protective action.
摘要
我们研究了硝酸甘油（NTG）对已产生血管性NTG耐受的大鼠离体工作心脏是否具有抗缺血作用。将来自耐受和非耐受大鼠的心脏在存在10⁻⁷ M NTG和/或其溶剂的情况下进行10分钟的冠状动脉闭塞。NTG减轻了缺血诱导的心脏功能恶化，并减少了乳酸脱氢酶的释放，而对来自NTG耐受和非耐受大鼠的心脏的冠状动脉血流以及缺血区面积均无影响。两组的效应大小相似。这些结果表明，NTG的抗缺血作用涉及独立于其血管作用的直接心肌机制，并且对NTG的血管耐受性并不影响这种直接的保护作用。
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