Buchanan N
Department of Paediatrics, Westmead Hospital, Sydney, Australia.
Seizure. 1995 Sep;4(3):233-6. doi: 10.1016/s1059-1311(05)80066-4.
This study reports the use of lamotrigine, largely as add-on therapy, in 34 children, adolescents and adults with brain damage and resistant seizures. Seventy-four percent of the patients showed a greater than 50% improvement in seizure control with 35% becoming seizure free. This improvement in seizure control was associated with an enhanced quality of life in 65% of the patients as assessed by improved alertness, mobility, speech and independence. It was possible to reduce 36% of the pre-existing antiepileptic drugs and the side effect profile of lamotrigine was very good. It is proposed that lamotrigine may be a particularly useful antiepileptic drug in this particular group of patients.
本研究报告了拉莫三嗪在34例脑损伤且癫痫发作难治的儿童、青少年及成人中的应用情况，主要作为附加治疗。74%的患者癫痫发作控制改善超过50%，35%的患者癫痫发作停止。通过改善警觉性、活动能力、言语及独立性评估，65%的患者癫痫发作控制的改善与生活质量提高相关。可以减少36%的原有抗癫痫药物，且拉莫三嗪的副作用情况非常良好。研究表明，拉莫三嗪在这一特定患者群体中可能是一种特别有用的抗癫痫药物。
