Deyo R A, Hittner J M
Department of Psychology, Winona State University, Minnesota 55987, USA.
Neurobiol Learn Mem. 1995 Jul;64(1):10-6. doi: 10.1006/nlme.1995.1039.
Recent studies report that the peripheral administration of Ca2+ channel antagonists improves memory while central administration impairs memory in neurologically intact subjects. This study compares the effects of systemic versus central administration of the Ca2+ channel antagonist flunarizine on visual discrimination learning. In Experiment 1, 60 five-day-old male chicks received an intraperitoneal injection of 0, 1, 10, or 25 mg/kg flunarizine. Each chick then received three post-treatment test sessions (+5 min, +30 min, and +24 h) consisting of 60 visual discrimination trials followed by 5 min of observation in an open field. Flunarizine produced a dose- and time-dependent facilitation of learning. Evaluation of open-field behaviors indicated that the dose of flunarizine required to increase spontaneous activity was 10 times higher than the dose required to facilitate visual discrimination learning. No other open-field behaviors were effected. In Experiment 2, 44 chicks received intracerbroventricular injections of 0, 100 nM, 100 micro M, or 1 mM flunarizine followed by visual discrimination training as described in Experiment 1. Ventricular injection of flunarizine significantly increased the number of errors made during acquisition and retention trials. These data are consistent with earlier studies showing that systemic, but not central, administration of Ca2+ channel antagonists facilitates learning.
近期研究报告称，在神经功能正常的受试者中，外周给予钙通道拮抗剂可改善记忆，而中枢给予则会损害记忆。本研究比较了钙通道拮抗剂氟桂利嗪全身给药与中枢给药对视觉辨别学习的影响。在实验1中，60只5日龄雄性雏鸡腹腔注射0、1、10或25mg/kg氟桂利嗪。然后，每只雏鸡接受三个治疗后测试阶段（+5分钟、+30分钟和+24小时），包括60次视觉辨别试验，随后在旷场中观察5分钟。氟桂利嗪对学习产生了剂量和时间依赖性的促进作用。对旷场行为的评估表明，增加自发活动所需的氟桂利嗪剂量比促进视觉辨别学习所需的剂量高10倍。没有其他旷场行为受到影响。在实验2中，44只雏鸡接受脑室内注射0、100nM、100μM或1mM氟桂利嗪，然后按照实验1所述进行视觉辨别训练。脑室内注射氟桂利嗪显著增加了习得和保持试验期间的错误数量。这些数据与早期研究一致，表明全身而非中枢给予钙通道拮抗剂可促进学习。
